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Article

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease.

The Journal of cell biology - 5 Nov 2007

Filimonenko Maria, Stuffers Susanne, Raiborg Camilla, Yamamoto Ai, Malerød Lene, Fisher Elizabeth M C, Isaacs Adrian, Brech Andreas, Stenmark Harald, Simonsen Anne

Abstract excerpt

The endosomal sorting complexes required for transport (ESCRTs) are required to sort integral membrane proteins into intralumenal vesicles of the multivesicular body (MVB). Mutations in the ESCRT-III subunit CHMP2B were recently associated with frontotemporal dementia and amyotrophic lateral sclerosis (ALS), neurodegenerative diseases characterized by abnormal ubiquitin-positive protein deposits in affected...

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PMID: 17984323
DOI: 10.1083/jcb.200702115
PMCID: PMC2064794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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