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Article

Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?

Molecular neurodegeneration - 28 Dec 2017

Deng Zhiqiang, Sheehan Patricia, Chen Shi, Yue Zhenyu

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative disorders that share genetic risk factors and pathological hallmarks. Intriguingly, these shared factors result in a high rate of comorbidity of these diseases in patients. Intracellular protein aggregates are a common pathological hallmark of both diseases. Emerging evidence suggests that impaired RNA processing and...

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Identifiers

PMID: 29282133
DOI: 10.1186/s13024-017-0232-6
PMCID: PMC5746010

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