Article
Functional analysis of N-terminal residues of ty1 integrase.
Journal of virology - 1 Sept 2009
Moore Sharon P, Garfinkel David J
Abstract excerpt
The Ty1 retrotransposon of Saccharomyces cerevisiae is comprised of structural and enzymatic proteins that are functionally similar to those of retroviruses. Despite overall sequence divergence, certain motifs are highly conserved. We have examined the Ty1 integrase (IN) zinc binding domain by mutating the definitive histidine and cysteine residues and thirteen residues in the intervening (X(32)) sequence between...
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