Article
Ty3 integrase is required for initiation of reverse transcription.
Journal of virology - 1 Mar 2002
Nymark-McMahon M Henrietta, Beliakova-Bethell Nadejda S, Darlix Jean-Luc, Le Grice Stuart F J, Sandmeyer Suzanne B
Abstract excerpt
The integrase (IN) encoded by the Saccharomyces cerevisiae retrovirus-like element Ty3 has features found in retrovirus IN proteins including the catalytic triad, an amino-terminal zinc-binding motif, and a nuclear localization sequence. Mutations in the amino- and carboxyl-terminal domains of Ty3 IN cause reduced accumulation of full-length cDNA in the viruslike particles. We show that the reduction in cDNA is...
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