Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure of a Ty1 restriction factor reveals the molecular basis of transposition copy number control.

Nature communications - 22 Sept 2021

Cottee Matthew A, Beckwith Sean L, Letham Suzanne C, Kim Sarah J, Young George R, Stoye Jonathan P, Garfinkel David J, Taylor Ian A

Abstract excerpt

Excessive replication of Saccharomyces cerevisiae Ty1 retrotransposons is regulated by Copy Number Control, a process requiring the p22/p18 protein produced from a sub-genomic transcript initiated within Ty1 GAG. In retrotransposition, Gag performs the capsid functions required for replication and re-integration. To minimize genomic damage, p22/p18 interrupts virus-like particle function by interaction with Gag....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins
Share to Capsid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Capsid Proteins

Share to Gene Products, gag

Share to Protein Domains

Share to Protein Multimerization

Share to Protein Stability

Share to Retroelements

Source

Open in PubMed Open full text

Identifiers

PMID: 34552077
DOI: 10.1038/s41467-021-25849-0
PMCID: PMC8458377

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure of a Ty1 restriction factor reveals the molecular basis of transposition copy number control.PMID 34552077Read ↗

The Ty1 Retrotransposon Restriction Factor p22 Targets Gag.Semantic proximity Read ↗

CPSF6 defines a conserved capsid interface that modulates HIV-1 replication.Semantic proximity Read ↗

Ty5 gag mutations increase retrotransposition and suggest a role for hydrogen bonding in the function of the nucleocapsid zinc finger.Semantic proximity Read ↗

Functional analysis of N-terminal residues of ty1 integrase.Semantic proximity Read ↗

A nucleosomal surface defines an integration hotspot for the Saccharomyces cerevisiae Ty1 retrotransposon.Semantic proximity Read ↗

<b>Structural determinants within the subunit protein of Ty1 virus‐like particles</b>Semantic proximity Read ↗

Evolution of Ty1 copy number control in yeast by horizontal transfer of a <i>gag</i> geneSemantic proximity Read ↗

Structures of vertebrate R2 retrotransposon complexes during target-primed reverse transcription and after second strand nickingSemantic proximity Read ↗

Structure-function analysis of Rny1 in tRNA cleavage and growth inhibition.Semantic proximity Read ↗

Structural basis for spumavirus GAG tethering to chromatinSemantic proximity Read ↗

BUD22 affects Ty1 retrotransposition and ribosome biogenesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Structural basis for Spt5-mediated recruitment of the Paf1 complex to chromatin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.