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Article

Mutations in nonconserved domains of Ty3 integrase affect multiple stages of the Ty3 life cycle.

Journal of virology - 1 Jan 1999

Nymark-McMahon M H, Sandmeyer S B

Abstract excerpt

Ty3, a retroviruslike element of Saccharomyces cerevisiae, transposes into positions immediately upstream of RNA polymerase III-transcribed genes. The Ty3 integrase (IN) protein is required for integration of the replicated, extrachromosomal Ty3 DNA. In retroviral IN, a conserved core region is sufficient for strand transfer activity. In this study, charged-to-alanine scanning mutagenesis was used to investigate...

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Identifiers

PMID: 9847351
DOI: 10.1128/JVI.73.1.453-465.1999
PMCID: PMC103852

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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