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Article

Poly(ADP-ribose) polymerase-1 polymorphisms, expression and activity in selected human tumour cell lines.

British journal of cancer - 21 Jul 2009

Zaremba T, Ketzer P, Cole M, Coulthard S, Plummer E R, Curtin N J

Abstract excerpt

BACKGROUND: Poly(ADP-ribose) polymerase-1 (PARP-1) is a DNA-binding enzyme activated by DNA breaks and involved in DNA repair and other cellular processes. Poly(ADP-ribose) polymerase activity can be higher in cancer than in adjacent normal tissue, but cancer predisposition is reported to be greater in individuals with a single-nucleotide polymorphism (SNP) V762A (T2444C) in the catalytic domain that reduces...

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Identifiers

PMID: 19568233
DOI: 10.1038/sj.bjc.6605166
PMCID: PMC2720202

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Source receipt: pubmed, retrieved 7 Sept 2026.

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