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Article

Polymorphism of the 5-HT transporter and response to antidepressants: randomised controlled trial

25 Jan 2011

Abstract excerpt

BACKGROUND: Antidepressants exhibit a variety of pharmacological actions including inhibition of the serotonin and noradrenaline transporters. We wished to investigate whether genetic variation could be used to target or personalise treatment, in a comparison of selective serotonin reuptake inhibitors (SSRIs) with noradrenaline reuptake inhibitors (NARIs). AIMS: To test the hypothesis that patients homozygous for...

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PMID: 21263010
DOI: 10.1192/bjp.bp.110.082727

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