Article
Troponin I and Tropomyosin regulate chromosomal stability and cell polarity.
Journal of cell science - 1 Aug 2009
Sahota Virender Kumar, Grau Benjamin Filip, Mansilla Alicia, Ferrús Alberto
Abstract excerpt
The Troponin-Tropomyosin (Tn-Tm) complex regulates muscle contraction through a series of Ca(2+)-dependent conformational changes that control actin-myosin interactions. Members of this complex in Drosophila include the actin-binding protein Troponin I (TnI), and two Tropomyosins (Tm1 and Tm2), which are thought to form heterodimers. We show here that pre-cellular embryos of TnI, Tm1 and Tm2 mutants exhibit...
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