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Article

The haplolethality paradox of the wupA gene in Drosophila.

PLoS genetics - 1 Mar 2021

Casas-Tintó Sergio, Ferrús Alberto

Abstract excerpt

Haplolethals (HL) are regions of diploid genomes that in one dose are fatal for the organism. Their biological meaning is obscure because heterozygous loss-of-function mutations result in dominant lethality (DL) and, consequently, should be under strong negative selection. We report an in depth study of the HL associated to the gene wings up A (wupA). It encodes 13 transcripts (A-M) that yield 11 protein isoforms...

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Identifiers

PMID: 33739971
DOI: 10.1371/journal.pgen.1009108
PMCID: PMC8011728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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