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Article

Combination of TNF-RII, CYP1A1 and GSTM1 polymorphisms and the risk of Japanese SLE: findings from the KYSS study.

Rheumatology (Oxford, England) - 1 Sept 2009

Horiuchi Takahiko, Washio Masakazu, Kiyohara Chikako, Tsukamoto Hiroshi, Tada Yoshifumi, Asami Toyoko, Ide Saburo, Kobashi Gen, Takahashi Hiroki

Abstract excerpt

OBJECTIVES: Association of the polymorphisms of the genes, TNF receptor type II gene (TNF-RII), cytochrome P4501A1 gene (CYP1A1) and glutathione S-transferase M1 gene (GSTM1), with SLE was investigated. TNF-RII mediates inflammatory and immune response, whereas CYP1A1 and GSTM1 are involved in the metabolism of xenobiotics. These three genes are involved in the generation of reactive oxygen species (ROS), which...

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Source

Identifiers

PMID: 19561157
DOI: 10.1093/rheumatology/kep166

Genes

GSTM1
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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