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Tumor necrosis factor receptor II and PTPN22 genes polymorphisms and the risk of systemic lupus erythematosus in Egyptian children.

Lupus - 1 Aug 2021

Eid Riham, Hammad Ayman, Abdelsalam Maha, Fathy Aya Ahmed, Abd-El Ghafaar Dena M, Elmarghany Eman B, El-Hanafy Aya A, Mostafa Nora, Niazey Nermeen A, Korkor Mai S, Hamdy Nashwa

Abstract excerpt

BACKGROUND: Many genes have been implicated in the pathogenesis of systemic lupus erythematosus (SLE). Tumor necrosis factor (TNF) is a potent cytokine stimulator acting through 2 cell surface receptors (TNFR I and II). TNFRII gene which controls expression of these receptors has been linked to SLE susceptibility through promoting apoptosis. Also; Protein tyrosine phosphatase non receptor 22 (PTPN22) gene...

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PMID: 34080911
DOI: 10.1177/09612033211020359

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