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Article

Insights into the enzyme-substrate interaction in the norovirus 3C-like protease.

Journal of biochemistry - 1 Oct 2009

Someya Yuichi, Takeda Naokazu

Abstract excerpt

The Glu54 residue of the norovirus 3C-like protease was implicated in proteolysis as a third-member carboxylate of the catalytic triad. The E54L mutant protease cleaved the sequence (133)LSFE/AP between the 3B and 3C regions of norovirus polyprotein, but did not cleave the sequence (198)ATSE/GK between the 3A and 3B. The 3BC junction mutation (3B-L133A or 3B-F135S) hampered the cleavage by the E54L protease,...

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PMID: 19556225
DOI: 10.1093/jb/mvp094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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