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Article

SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity.

Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 2016

Muramatsu Tomonari, Takemoto Chie, Kim Yong-Tae, Wang Hongfei, Nishii Wataru, Terada Takaho, Shirouzu Mikako, Yokoyama Shigeyuki

Abstract excerpt

The 3C-like protease (3CLpro) of severe acute respiratory syndrome coronavirus (SARS-CoV) cleaves 11 sites in the polyproteins, including its own N- and C-terminal autoprocessing sites, by recognizing P4-P1 and P1'. In this study, we determined the crystal structure of 3CLpro with the C-terminal prosequence and the catalytic-site C145A mutation, in which the enzyme binds the C-terminal prosequence of another...

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Identifiers

PMID: 27799534
DOI: 10.1073/pnas.1601327113
PMCID: PMC5135343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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