Article
Mutations in the mitochondrial genome confer resistance of cancer cells to anticancer drugs.
Cancer science - 1 Sept 2009
Mizutani Satoshi, Miyato Yasuyuki, Shidara Yujiro, Asoh Sadamitsu, Tokunaga Akira, Tajiri Takashi, Ohta Shigeo
Abstract excerpt
The majority of cancer cells harbor homoplasmic somatic mutations in the mitochondrial genome. We show here that mutations in mitochondrial DNA (mtDNA) are responsible for anticancer drug tolerance. We constructed several trans-mitochondrial hybrids (cybrids) with mtDNA derived from human pancreas cancer cell lines CFPAC-1 and CAPAN-2 as well as from healthy individuals. These cybrids contained the different...
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