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Article

Apoptosis-resistant phenotype selected by alternating exposure to camptothecin and etoposide.

Experimental cell research - 25 Aug 1997

Kubota M, Usami I, Watanabe K i, Sawada M, Kataoka A, Koishi S, Lin Y W, Akiyama Y, Furusho K

Abstract excerpt

We selected an apoptosis-resistant subline (VC-33) in a human promyelocytic leukemia cell line, HL-60, by alternating exposure to camptothecin (CPT) and etoposide (VP-16). When wild-type (WT) and VC-33 cells were incubated with various concentrations of either CPT or VP-16 for 4 h, VC-33 showed several-fold resistance to apoptosis induced by these agents in comparison with WT cells. VC-33 cells also exhibited...

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Identifiers

PMID: 9281362
DOI: 10.1006/excr.1997.3634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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