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Article

Transfer of chloramphenicol-resistant mitochondrial DNA into the chimeric mouse.

Transgenic research - 1 Apr 1999

Levy S E, Waymire K G, Kim Y L, MacGregor G R, Wallace D C

Abstract excerpt

The mitochondrial DNA (mtDNA) chloramphenicol (CAP)-resistance (CAPR) mutation has been introduced into the tissues of adult mice via female embryonic stem (ES) cells. The endogenous CAP-sensitive (CAPS) mtDNAs were eliminated by treatment of the ES cells with the lipophilic dye Rhodamine-6-G (R-6-G). The ES cells were then fused to enucleated cell cytoplasts prepared from the CAPR mouse cell line 501-1. This...

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Source

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Identifiers

PMID: 10481313
DOI: 10.1023/a:1008967412955
PMCID: PMC3049807

Genes

CAPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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