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Article

Susceptibility locus in neurokinin-1 receptor gene associated with alcohol dependence.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2009

Seneviratne Chamindi, Ait-Daoud Nassima, Ma Jennie Z, Chen Guobo, Johnson Bankole A, Li Ming D

Abstract excerpt

Substance P (SP), a neurotransmitter in stress pathways, exerts its effects mainly through the neurokinin-1 receptor (NK1R). Genetic and pharmacological studies show that binding of ligands to NK1R decreases anxiety-related behaviors, and therefore, self-administration of alcohol in mice and craving for alcohol in humans. As genetic variants may result in differential expression of the receptor through various...

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Identifiers

PMID: 19553914
DOI: 10.1038/npp.2009.65
PMCID: PMC2743763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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