Article
Common body mass index-associated variants confer risk of extreme obesity.
Human molecular genetics - 15 Sept 2009
Cotsapas Chris, Speliotes Elizabeth K, Hatoum Ida J, Greenawalt Danielle M, Dobrin Radu, Lum Pek Y, Suver Christine, Chudin Eugene, Kemp Daniel, Reitman Marc, Voight Benjamin F, Neale Benjamin M, Schadt Eric E, Hirschhorn Joel N, Kaplan Lee M, Daly Mark J
Abstract excerpt
To investigate the genetic architecture of severe obesity, we performed a genome-wide association study of 775 cases and 3197 unascertained controls at approximately 550,000 markers across the autosomal genome. We found convincing association to the previously described locus including the FTO gene. We also found evidence of association at a further six of 12 other loci previously reported to influence body mass...
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