Article
Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies.
The American journal of clinical nutrition - 1 Jan 2010
Li Shengxu, Zhao Jing Hua, Luan Jian'an, Luben Robert N, Rodwell Sheila A, Khaw Kay-Tee, Ong Ken K, Wareham Nicholas J, Loos Ruth J F
Abstract excerpt
BACKGROUND: Large-scale genome-wide association studies have identified 12 genetic loci that are robustly associated with body mass index (BMI). OBJECTIVES: We examined associations and compared effect sizes of these newly identified obesity susceptibility loci with various anthropometric traits and assessed their cumulative effects and predictive value for obesity risk. DESIGN: We genotyped 12 single nucleotide...
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