Article
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.
Science (New York, N.Y.) - 11 May 2007
Frayling Timothy M, Timpson Nicholas J, Weedon Michael N, Zeggini Eleftheria, Freathy Rachel M, Lindgren Cecilia M, Perry John R B, Elliott Katherine S, Lango Hana, Rayner Nigel W, Shields Beverley, Harries Lorna W, Barrett Jeffrey C, Ellard Sian, Groves Christopher J, Knight Bridget, Patch Ann-Marie, Ness Andrew R, Ebrahim Shah, Lawlor Debbie A, Ring Susan M, Ben-Shlomo Yoav, Jarvelin Marjo-Riitta, Sovio Ulla, Bennett Amanda J, Melzer David, Ferrucci Luigi, Loos Ruth J F, Barroso Inês, Wareham Nicholas J, Karpe Fredrik, Owen Katharine R, Cardon Lon R, Walker Mark, Hitman Graham A, Palmer Colin N A, Doney Alex S F, Morris Andrew D, Smith George Davey, Hattersley Andrew T, McCarthy Mark I
Abstract excerpt
Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the...
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