Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.

doi:10.1371/journal.pgen.0030115

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Article

Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.

PLoS genetics - 1 Jul 2007

Scuteri Angelo, Sanna Serena, Chen Wei-Min, Uda Manuela, Albai Giuseppe, Strait James, Najjar Samer, Nagaraja Ramaiah, Orrú Marco, Usala Gianluca, Dei Mariano, Lai Sandra, Maschio Andrea, Busonero Fabio, Mulas Antonella, Ehret Georg B, Fink Ashley A, Weder Alan B, Cooper Richard S, Galan Pilar, Chakravarti Aravinda, Schlessinger David, Cao Antonio, Lakatta Edward, Abecasis Gonçalo R

Abstract excerpt

The obesity epidemic is responsible for a substantial economic burden in developed countries and is a major risk factor for type 2 diabetes and cardiovascular disease. The disease is the result not only of several environmental risk factors, but also of genetic predisposition. To take advantage of recent advances in gene-mapping technology, we executed a genome-wide association scan to identify genetic variants...

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Identifiers

PMID: 17658951
DOI: 10.1371/journal.pgen.0030115
PMCID: PMC1934391

Genes

FTO
PFKP

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Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.PMID 17658951Read ↗

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