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Haemophilus ducreyi SapA Contributes to Cathelicidin Resistance and Virulence in Humans

19 Jan 2010

Abstract excerpt

Haemophilus ducreyi is an extracellular pathogen of human epithelial surfaces that resists human antimicrobial peptides (APs). The organism's genome contains homologs of genes sensitive to antimicrobial peptides (sap operon) in nontypeable Haemophilus influenzae. In this study, we characterized the sap-containing loci of H. ducreyi 35000HP and demonstrated that sapA is expressed in broth cultures and H....

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PMID: 20086092
DOI: 10.1128/iai.01014-09

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