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Helicobacter pylori luxS mutants cause hyperinflammatory responses during chronic infection.

Microbiology spectrum - 7 Jan 2025

Yang Christina, Rodriguez Y Baena Alessandra, Manso Bryce A, Hu Shuai, Lopez-Magaña Raymondo, Ohanyan Mané, Ottemann Karen M

Abstract excerpt

Helicobacter pylori infects roughly half the world's population, causing gastritis, peptic ulcers, and gastric cancer in a subset. These pathologies occur in response to a chronic inflammatory state, but it is not fully understood how H. pylori controls this process. We characterized the inflammatory response of H. pylori mutants that cannot produce the quorum sensing molecule autoinducer 2 (AI-2) by deleting the...

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PMID: 39641542
DOI: 10.1128/spectrum.01073-24

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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