Article
Active Notch1 confers a transformed phenotype to primary human melanocytes.
Cancer research - 1 Jul 2009
Pinnix Chelsea C, Lee John T, Liu Zhao-Jun, McDaid Ronan, Balint Klara, Beverly Levi J, Brafford Patricia A, Xiao Min, Himes Benjamin, Zabierowski Susan E, Yashiro-Ohtani Yumi, Nathanson Katherine L, Bengston Ana, Pollock Pamela M, Weeraratna Ashani T, Nickoloff Brian J, Pear Warren S, Capobianco Anthony J, Herlyn Meenhard
Abstract excerpt
The importance of mitogen-activated protein kinase signaling in melanoma is underscored by the prevalence of activating mutations in N-Ras and B-Raf, yet clinical development of inhibitors of this pathway has been largely ineffective, suggesting that alternative oncogenes may also promote melanoma. Notch is an interesting candidate that has only been correlated with melanoma development and progression; a...
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