Article
The role of BRAF mutation and p53 inactivation during transformation of a subpopulation of primary human melanocytes.
The American journal of pathology - 1 Jun 2009
Yu Hong, McDaid Ronan, Lee John, Possik Patricia, Li Ling, Kumar Suresh M, Elder David E, Van Belle Patricia, Gimotty Phyllis, Guerra Matt, Hammond Rachel, Nathanson Katharine L, Dalla Palma Maria, Herlyn Meenhard, Xu Xiaowei
Abstract excerpt
Melanocytic nevi frequently harbor oncogenic BRAF mutations, but only a minority progress to melanoma. In human melanocytes, persistent BRAF(V600E) expression triggers oncogene-induced senescence, which implies that bypass of oncogene-induced senescence is necessary for malignant transformation of melanocytes. We show that a subpopulation of primary human melanocytes with persistent expression of BRAF(V600E) do...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.