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Article

Amino acid polymorphisms altering the glycosylation of IL-2 do not protect from type 1 diabetes in the NOD mouse.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 2009

Kamanaka Masahito, Rainbow Dan, Schuster-Gossler Karin, Eynon Elizabeth E, Chervonsky Alexander V, Wicker Linda S, Flavell Richard A

Abstract excerpt

Idd3 is one of many gene regions that affect the development of type 1 diabetes (T1D) in the nonobese diabetic (NOD) mouse. Idd3 has been localized to a 650-kb region on chromosome 3 containing the IL-2 gene. Exon 1 of the IL-2 gene is polymorphic between the susceptible NOD and the protective C57BL/6 (B6) alleles, causing multiple amino acid changes that have been proposed to be responsible for the differing...

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Identifiers

PMID: 19549859
DOI: 10.1073/pnas.0904780106
PMCID: PMC2700154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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