Article
Differential glycosylation of interleukin 2, the molecular basis for the NOD Idd3 type 1 diabetes gene?
Cytokine - 1 May 2000
Podolin P L, Wilusz M B, Cubbon R M, Pajvani U, Lord C J, Todd J A, Peterson L B, Wicker L S, Lyons P A
Abstract excerpt
The insulin-dependent diabetes (Idd) gene, Idd3, has been localised to a 0.35 cM region of chromosome 3 containing the structural gene for the cytokine interleukin 2 (IL-2). While variation of the N-terminal amino acid sequence of IL-2 has been shown to correlate with Idd3 allelic variation, differences in induction of proliferation by IL-2 allotypes have not been detected. In the current study, we examined the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.