Article
Absence of SH2B3 mutation in nonobese diabetic mice.
Genetics and molecular research : GMR - 9 May 2012
Li Y J, Li X Y, Guo X R, Li Y, Shen B F, Shi Y C, Zhang J Y
Abstract excerpt
Type 1 diabetes is a chronic progressive autoimmune disease characterized by mononuclear cell infiltration, with subsequent destruction of insulin-producing β-cells. Studies have identified strong associations between type 1 diabetes and several chromosome regions, including 12q24. Association between type 1 diabetes and 12q24 arises from SNP rs3184504; rs3184504 is a nonsynonymous SNP in exon 3 of SH2B3...
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