Article
Mutant thyroid hormone receptor beta represses the expression and transcriptional activity of peroxisome proliferator-activated receptor gamma during thyroid carcinogenesis.
Cancer research - 1 Sept 2003
Ying Hao, Suzuki Hideyo, Zhao Li, Willingham Mark C, Meltzer Paul, Cheng Sheue-Yann
Abstract excerpt
The molecular genetics underlying thyroid carcinogenesis is not clear. Recent identification of a PAX8-peroxisome proliferator-activated receptor gamma (PPARgamma) fusion gene in human thyroid follicular carcinoma suggests a tumor suppressor role of PPARgamma in thyroid carcinogenesis. Mice harboring a knockin mutant thyroid hormone beta receptor (TRbetaPV) spontaneously develop thyroid follicular carcinoma...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.