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Article

Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis.

The Journal of clinical investigation - 1 Oct 2012

Xuan Shouhong, Borok Matthew J, Decker Kimberly J, Battle Michele A, Duncan Stephen A, Hale Michael A, Macdonald Raymond J, Sussel Lori

Abstract excerpt

Pancreatic agenesis is a human disorder caused by defects in pancreas development. To date, only a few genes have been linked to pancreatic agenesis in humans, with mutations in pancreatic and duodenal homeobox 1 (PDX1) and pancreas-specific transcription factor 1a (PTF1A) reported in only 5 families with described cases. Recently, mutations in GATA6 have been identified in a large percentage of human cases, and...

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Source

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Identifiers

PMID: 23006325
DOI: 10.1172/JCI63352
PMCID: PMC3461916

Genes

GATA4
GATA6
CPA1
NEUROG3
PDX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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