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Article

Allele-specific regulation of MTTP expression influences the risk of ischemic heart disease.

Journal of lipid research - 1 Jan 2010

Aminoff Anna, Ledmyr Helena, Thulin Petra, Lundell Kerstin, Nunez Leyla, Strandhagen Elisabeth, Murphy Charlotte, Lidberg Ulf, Westerbacka Jukka, Franco-Cereceda Anders, Liska Jan, Nielsen Lars Bo, Gåfvels Mats, Mannila Maria Nastase, Hamsten Anders, Yki-Järvinen Hannele, Thelle Dag, Eriksson Per, Borén Jan, Ehrenborg Ewa

Abstract excerpt

Promoter polymorphisms in microsomal triglyceride transfer protein (MTTP) have been associated with decreased plasma lipids but an increased risk for ischemic heart disease (IHD), indicating that MTTP influences the susceptibility for IHD independent of plasma lipids. The objective of this study was to characterize the functional promoter polymorphism in MTTP predisposing to IHD and its underlying mechanism. Use...

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Source

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Identifiers

PMID: 19546343
DOI: 10.1194/jlr.M900195-JLR200
PMCID: PMC2789770

Genes

MTTP
EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Allele-specific regulation of MTTP expression influences the risk of ischemic heart disease.PMID 19546343Read ↗

Functional analysis of promoter variants in the microsomal triglyceride transfer protein (MTTP) gene.Semantic proximity Read ↗

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