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Article

The microsomal triglyceride transfer protein gene-493T variant lowers cholesterol but increases the risk of coronary heart disease.

Circulation - 18 May 2004

Ledmyr Helena, McMahon Alex D, Ehrenborg Ewa, Nielsen Lars B, Neville Matt, Lithell Hans, MacFarlane Peter W, Packard Christopher J, Karpe Fredrik

Abstract excerpt

BACKGROUND: The microsomal triglyceride transfer protein (MTP) transfers lipids into apolipoprotein B-containing lipoproteins for secretion from liver, intestine, and heart. The T-variant of a functional polymorphism in the MTP promoter, MTP-493G/T, has been associated with reduced low-density lipoprotein cholesterol concentrations. We hypothesize that this polymorphism impacts on coronary heart disease (CHD)...

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Source

Identifiers

PMID: 15136504
DOI: 10.1161/01.CIR.0000130070.96758.7b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The microsomal triglyceride transfer protein gene-493T variant lowers cholesterol but increases the risk of coronary heart disease.PMID 15136504Read ↗

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