Article
CpG methylation regulates the Igf2/H19 insulator.
Current biology : CB - 24 Jul 2001
Holmgren C, Kanduri C, Dell G, Ward A, Mukhopadhya R, Kanduri M, Lobanenkov V, Ohlsson R
Abstract excerpt
The differentially methylated 5'-flank of the mouse H19 gene unidirectionally regulates the communication between enhancer elements and gene promoters and presumably represses maternal Igf2 expression in vivo [1-6]. The specific activation of the paternally inherited Igf2 allele has been proposed to involve methylation-mediated inactivation of the H19 insulator function during male germline development [1-4, 6]....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.