Genomic imprinting recapitulated in the human β-globin locus

doi:10.1073/pnas.0409541102

Article

Genomic imprinting recapitulated in the human β-globin locus

8 Jul 2005

Abstract excerpt

A subset of genes in mammals are subject to genomic imprinting. The mouse H19 gene, for example, is active only when maternally inherited and the neighboring Igf2 gene is paternally expressed. This imprinted expression pattern is regulated by the imprinting control region (ICR) upstream of the H19 gene. A maternally inherited H19 ICR inhibits Igf2 gene activation by the downstream enhancer due to its insulator...

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