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Article

Fate of methylated/unmethylated H19 imprinting control region after paternal and maternal pronuclear injection.

Experimental animals - 30 Oct 2017

Oji Asami, Amano Tomojiro, Maeta Yasuaki, Hori Naohiro, Hatsuzawa Kiyotaka, Sato Kenzo, Nakanishi Tomoko

Abstract excerpt

The paternal-allele-specific methylation of the Igf2/H19 imprinting control region (ICR) is established during gametogenesis and maintained throughout development. To elucidate the requirement of the germline passage in the maintenance of the imprinting methylation, we established a system introducing a methylated or unmethylated ICR-containing DNA fragment (ICR-F) into the paternal or maternal genome by...

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Source

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Identifiers

PMID: 28674270
DOI: 10.1538/expanim.17-0031
PMCID: PMC5682349

Genes

CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fate of methylated/unmethylated H19 imprinting control region after paternal and maternal pronuclear injection.PMID 28674270Read ↗

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Synthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic miceSemantic proximity Read ↗

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A Randomly Integrated Transgenic <i>H19</i> Imprinting Control Region Acquires Methylation Imprinting Independently of Its Establishment in Germ CellsSemantic proximity Read ↗

The transgenic IG-DMR sequence of the mouse Dlk1-Dio3 domain acquired imprinted DNA methylation during the post-fertilization periodSemantic proximity Read ↗

Oct4/Sox2 binding sites contribute to maintaining hypomethylation of the maternal igf2/h19 imprinting control region.Semantic proximity Read ↗

<i>H19</i> Imprinting Control Region Methylation Requires an Imprinted Environment Only in the Male Germ LineSemantic proximity Read ↗

CTCF binding is not the epigenetic mark that establishes post-fertilization methylation imprinting in the transgenic H19 ICR.Semantic proximity Read ↗

CTCF elements direct allele-specific undermethylation at the imprinted H19 locus.Semantic proximity Read ↗

CTCF maintains differential methylation at the Igf2/H19 locus.Semantic proximity Read ↗

Role of CTCF binding sites in the Igf2/H19 imprinting control region.Semantic proximity Read ↗

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