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The H19 Imprinting Control Region Mediates Preimplantation Imprinted Methylation of Nearby Sequences in Yeast Artificial Chromosome Transgenic Mice

11 Dec 2012

Abstract excerpt

In the mouse Igf2/H19 imprinted locus, differential methylation of the imprinting control region (H19 ICR) is established during spermatogenesis and is maintained in offspring throughout development. Previously, however, we observed that the paternal H19 ICR, when analyzed in yeast artificial chromosome transgenic mice (YAC-TgM), was preferentially methylated only after fertilization. To identify the DNA...

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PMID: 23230275
DOI: 10.1128/mcb.01003-12

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The H19 Imprinting Control Region Mediates Preimplantation Imprinted Methylation of Nearby Sequences in Yeast Artificial Chromosome Transgenic MicePMID 23230275Read ↗

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A Randomly Integrated Transgenic <i>H19</i> Imprinting Control Region Acquires Methylation Imprinting Independently of Its Establishment in Germ CellsSemantic proximity Read ↗

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