Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The BCR-ABL inhibitor nilotinib influences phenotype and function of monocyte-derived human dendritic cells.

Cancer immunology, immunotherapy : CII - 1 May 2018

Dörfel Daniela, Lechner Christian J, Joas Simone, Funk Tanja, Gutknecht Michael, Salih Julia, Geiger Julian, Kropp Korbinian N, Maurer Stefanie, Müller Martin R, Kopp Hans-Georg, Salih Helmut R, Grünebach Frank, Rittig Susanne M

Abstract excerpt

In chronic myeloid leukemia (CML), the translocation t(9;22) results in the fusion protein BCR-ABL (breakpoint cluster region-abelson murine leukemia), a tyrosine kinase mediating oncogenic signaling which is successfully targeted by treatment with BCR-ABL inhibitors like imatinib. However, BCR-ABL inhibitors may also affect antitumor immunity. For instance, it was reported that imatinib impairs the function of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to Dendritic Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fusion Proteins, bcr-abl

Share to Imatinib Mesylate

Share to Monocytes

Share to Phenotype

Share to Protein Kinase Inhibitors

Share to Pyrimidines

Source

Open in PubMed Open full text

Identifiers

PMID: 29468363
DOI: 10.1007/s00262-018-2129-9
PMCID: PMC11028318

Genes

BCR
CCL2
CCL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The BCR-ABL inhibitor nilotinib influences phenotype and function of monocyte-derived human dendritic cells.PMID 29468363Read ↗

Imatinib mesylate minimally affects bcr-abl+ and normal monocyte-derived dendritic cells but strongly inhibits T cell expansion despite reciprocal dendritic cell-T cell activation.Semantic proximity Read ↗

Imatinib and Nilotinib Off-Target Effects on Human NK Cells, Monocytes, and M2 MacrophagesSemantic proximity Read ↗

A MALDI-TOF assay identifies nilotinib as an inhibitor of inflammation in acute myeloid leukaemiaSemantic proximity Read ↗

Development, Function, and Clinical Significance of Plasmacytoid Dendritic Cells in Chronic Myeloid Leukemia.Semantic proximity Read ↗

Assessment of bone marrow lymphocytic status during tyrosine kinase inhibitor therapy and its relation to therapy response in chronic myeloid leukaemia.Semantic proximity Read ↗

The transcription factor MITF is a critical regulator of GPNMB expression in dendritic cellsSemantic proximity Read ↗

Improving frontline treatment for chronic myeloid leukemia: emerging evidence for use of nilotinib and dasatinib.Semantic proximity Read ↗

Induction of suppressive phenotype in monocyte-derived dendritic cells by leukemic cell products and IL-1β.Semantic proximity Read ↗

A gene signature of inhibitory MHC receptors identifies a BDCA3(+) subset of IL-10-induced dendritic cells with reduced allostimulatory capacity in vitro.Semantic proximity Read ↗

Neutrophil granulocyte-committed cells can be driven to acquire dendritic cell characteristics.Semantic proximity Read ↗

BCR/ABL Oncogene Directly Controls MHC Class I Chain-Related Molecule A Expression in Chronic Myelogenous LeukemiaSemantic proximity Read ↗

Modulatory effect of rapamycin and tacrolimus on monocyte-derived dendritic cells phenotype and function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.