Article
Initiation of dopaminergic differentiation of Nurr1(-) mesencephalic precursor cells depends on activation of multiple mitogen-activated protein kinase pathways.
Stem cells (Dayton, Ohio) - 1 Aug 2009
Sabolek Michael, Baumann Bernd, Heinrich Maria, Meyer Anne K, Herborg Anna, Liebau Stefan, Maisel Martina, Hermann Andreas, Ventz Katharina, Schwarz Johannes, Wirth Thomas, Storch Alexander
Abstract excerpt
Interleukin-1 (IL-1) plays a pivotal role in terminal dopaminergic differentiation of midbrain-derived neural precursor cells already committed to the mesencephalic dopaminergic phenotype (named mdNPCs for mesencephalic dopaminergic neural precursor cells). Here we characterized the molecular events in long-term expanded rat nuclear receptor related-1(-) (Nurr1(-)) mdNPCs in response to IL-1beta during their...
Topics
- Animals
- Cell Differentiation
- Cell Growth Processes
- Cells, Cultured
- DNA-Binding Proteins
- Immunohistochemistry
- Interleukin-1beta
- MAP Kinase Signaling System
- Mesencephalon
- Mitogen-Activated Protein Kinases
- NF-kappa B
- Neurons