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Article

Sonic hedgehog and FGF8 collaborate to induce dopaminergic phenotypes in the Nurr1-overexpressing neural stem cell.

Biochemical and biophysical research communications - 13 Jun 2003

Kim Tae Eun, Lee Hack Sup, Lee Yong Beom, Hong Seung Hwan, Lee Young Seek, Ichinose Hiroshi, Kim Seung U, Lee Myung Ae

Abstract excerpt

Neural stem cells are self-renewing cells capable of differentiating into all neural lineage cells in vivo and in vitro. In the present study, coordinated induction of midbrain dopaminergic phenotypes in an immortalized multipotent neural stem cell line can be achieved by both overexpression of nuclear receptor Nurr1, and fibroblast growth factor-8 (FGF-8), and sonic hedgehog (Shh) signals. Nurr1 overexpression...

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Source

Identifiers

PMID: 12767935
DOI: 10.1016/s0006-291x(03)00879-9

Genes

FGF8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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