Article
EpCAM is involved in maintenance of the murine embryonic stem cell phenotype.
Stem cells (Dayton, Ohio) - 1 Aug 2009
González Bárbara, Denzel Sabine, Mack Brigitte, Conrad Marcus, Gires Olivier
Abstract excerpt
Epithelial cell adhesion molecule EpCAM is a transmembrane glycoprotein that is expressed on subsets of normal epithelia, numerous stem- and progenitor-type cells, and most carcinomas and highly overexpressed on cancer-initiating cells. The role of EpCAM in early development, particularly in stem-like cells, has remained unclear. Here, we show that the maintenance of self-renewal in murine embryonic stem (ES)...
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