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Article

Immunohistochemical and molecular pattern of p53 in epithelial ovarian cancers negative for germline BRCA1/2 variants.

Pathology, research and practice - 1 Mar 2024

Ronchi Susanna, Facchi Sofia, Di Lauro Eleonora, Libera Laura, Carnevali Ileana Wanda, Zefiro Francesca, Alexandrova Elena, Rizzo Francesca, Sessa Fausto, Tibiletti Maria Grazia

Abstract excerpt

Epithelial ovarian cancers (EOC) associated with germline or somatic BRCA pathogenetic variants have a significantly higher rate of TP53aberrations. The majority of TP53 mutations are detectable by immunohistochemistry and several studies demonstrated that an abnormal p53 pattern characterized high-grade EOCs. An abnormal p53 immunohistochemical staining in fallopian tube (serous tubal intraepithelial carcinoma...

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Identifiers

PMID: 38364651
DOI: 10.1016/j.prp.2024.155183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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