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Article

Inactivation of the GATA Cofactor ZFPM1 Results in Abnormal Development of Dorsal Raphe Serotonergic Neuron Subtypes and Increased Anxiety-Like Behavior.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 Nov 2020

Tikker Laura, Casarotto Plinio, Singh Parul, Biojone Caroline, Piepponen T Petteri, Estartús Nuri, Seelbach Anna, Sridharan Ravindran, Laukkanen Liina, Castrén Eero, Partanen Juha

Abstract excerpt

Serotonergic neurons in the dorsal raphe (DR) nucleus are associated with several psychiatric disorders including depression and anxiety disorders, which often have a neurodevelopmental component. During embryonic development, GATA transcription factors GATA2 and GATA3 operate as serotonergic neuron fate selectors and regulate the differentiation of serotonergic neuron subtypes of DR. Here, we analyzed the...

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PMID: 33046550
DOI: 10.1523/JNEUROSCI.2252-19.2020
PMCID: PMC7643297

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