Article
Ascl1 Is Required for the Development of Specific Neuronal Subtypes in the Enteric Nervous System.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Apr 2016
Memic Fatima, Knoflach Viktoria, Sadler Rebecca, Tegerstedt Gunilla, Sundström Erik, Guillemot Francois, Pachnis Vassilis, Marklund Ulrika
Abstract excerpt
The enteric nervous system (ENS) is organized into neural circuits within the gastrointestinal wall where it controls the peristaltic movements, secretion, and blood flow. Although proper gut function relies on the complex neuronal composition of the ENS, little is known about the transcriptional networks that regulate the diversification into different classes of enteric neurons and glia during development. Here...
Topics
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Calbindins
- Cell Differentiation
- Enteric Nervous System
- Female
- Humans
- Mice
- Mice, Knockout
- Mice, Transgenic
- Mutation
- Neural Stem Cells
- Neurogenesis