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Article

Sim1 is a novel regulator in the differentiation of mouse dorsal raphe serotonergic neurons.

PloS one - 26 Apr 2011

Osterberg Nadja, Wiehle Michael, Oehlke Oliver, Heidrich Stefanie, Xu Cheng, Fan Chen-Ming, Krieglstein Kerstin, Roussa Eleni

Abstract excerpt

BACKGROUND: Mesencephalic dopaminergic neurons (mDA) and serotonergic (5-HT) neurons are clinically important ventral neuronal populations. Degeneration of mDA is associated with Parkinson's disease; defects in the serotonergic system are related to depression, obsessive-compulsive disorder, and schizophrenia. Although these neuronal subpopulations reveal positional and developmental relationships, the...

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Identifiers

PMID: 21541283
DOI: 10.1371/journal.pone.0019239
PMCID: PMC3082558

Genes

RGS4

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