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Article

Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 Nov 2003

Cheng Leping, Chen Chih-Li, Luo Ping, Tan Min, Qiu Mengsheng, Johnson Randy, Ma Qiufu

Abstract excerpt

Serotonergic (5-HT) neurons in the brainstem modulate a wide range of physiological processes and behaviors. Two transcription factor genes, Pet-1 and Nkx2.2, are necessary but not sufficient to specify the 5-HT transmitter phenotype. Here we show that the Lim class homeobox gene Lmx1b is required for proper formation of the entire 5-HT system in the hindbrain, as indicated by the loss of expression of genes...

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PMID: 14602809
PMCID: PMC6740868

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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