Article
Glutathionylation mediates angiotensin II-induced eNOS uncoupling, amplifying NADPH oxidase-dependent endothelial dysfunction.
Journal of the American Heart Association - 22 Apr 2014
Galougahi Keyvan Karimi, Liu Chia-Chi, Gentile Carmine, Kok Cindy, Nunez Andrea, Garcia Alvaro, Fry Natasha A S, Davies Michael J, Hawkins Clare L, Rasmussen Helge H, Figtree Gemma A
Abstract excerpt
BACKGROUND: Glutathionylation of endothelial nitric oxide synthase (eNOS) "uncouples" the enzyme, switching its function from nitric oxide (NO) to O2(•-) generation. We examined whether this reversible redox modification plays a role in angiotensin II (Ang II)-induced endothelial dysfunction. METHODS AND RESULTS: Ang II increased eNOS glutathionylation in cultured human umbilical vein endothelial cells (HUVECs),...
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