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Comparative analysis of copy number detection by whole-genome BAC and oligonucleotide array CGH

29 Jun 2010

Abstract excerpt

BACKGROUND: Microarray-based comparative genomic hybridization (aCGH) is a powerful diagnostic tool for the detection of DNA copy number gains and losses associated with chromosome abnormalities, many of which are below the resolution of conventional chromosome analysis. It has been presumed that whole-genome oligonucleotide (oligo) arrays identify more clinically significant copy-number abnormalities than...

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PMID: 20587050
DOI: 10.1186/1755-8166-3-11

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