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Article

Detection of ≥1 Mb microdeletions and microduplications in a single cell using custom oligonucleotide arrays

1 Jan 2012

Abstract excerpt

OBJECTIVE: High resolution detection of genomic copy number abnormalities in a single cell is relevant to preimplantation genetic diagnosis and potentially to noninvasive prenatal diagnosis. Our objective is to develop a reliable array comparative genomic hybridization (CGH) platform to detect genomic imbalances as small as ~1Mb ina single cell. METHODS: We empirically optimized the conditions for...

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Share to Genomic variations and chromosomal abnormalities
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PMID: 22470934
DOI: 10.1002/pd.2855

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