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High-resolution array comparative genomic hybridization of single micrometastatic tumor cells

15 Mar 2008

Abstract excerpt

Only few selected cancer cells drive tumor progression and are responsible for therapy resistance. Their specific genomic characteristics, however, are largely unknown because high-resolution genome analysis is currently limited to DNA pooled from many cells. Here, we describe a protocol for array comparative genomic hybridization (array CGH), which enables the detection of DNA copy number changes in single...

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PMID: 18344524
DOI: 10.1093/nar/gkn101

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